Aryl Hydrocarbon Receptor Agonist
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AhR agonist 8
0 ImagesCat. No.: HY-168033CAS No.: 3036895-67-4AhR agonist 8 (compound 9) is a potent Aryl Hydrocarbon Receptor (AhR) agonist with an EC50 of 0.154 nM. AhR agonist 8 can be used in the study of psoriasis and atopic dermatitis.
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AhR agonist 6
0 ImagesCat. No.: HY-158168CAS No.: 3033281-96-5AhR agonist 6 (Compound 6) is an agonist for aryl hydrocarbon receptor (AhR), with an EC50 of 0.01 nM.
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AFP464
0 ImagesCat. No.: HY-16031ACAS No.: 468719-53-1Synonyms: NSC710464AFP464 (NSC710464) is a prodrug of Aminoflavone (HY-132974) and an agonist of the aryl hydrocarbon receptor (AhR). AFP464 downregulates the expression of α6-integrin (α6-integrin), inhibits breast tumor growth, reduces the population of tumor-initiating cells, disrupts mammosphere structure, induces the formation of mucin lake clusters, triggers DNA damage, and exerts antiproliferative activity. AFP464 is rapidly converted to Aminoflavone by nonspecific esterases in plasma and cell culture media. AFP464 is applicable to research related to breast cancer.
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AHR agonist 4
0 ImagesCat. No.: HY-155505CAS No.: 2953023-30-6AHR agonist 4 (compound 24e) is an agonist of Aryl hydrocarbon receptor (AHR), assocaited with the immune balance of Th17/22 and Treg cells. AHR agonist 4 serves as a lead compound for anti-psoriasis drug, alleviates imiquimod (IMQ)-induced psoriasis-like skin lesion. AHR agonist 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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AhR agonist 7
0 ImagesCat. No.: HY-158169CAS No.: 3033281-98-7AhR agonist 7 (Compound 8) has a good activation activity against AhR (ECsub>50 = 13nM).
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L-Kynurenine sulfate
0 ImagesL-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype.
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1-Hydroxypyrene (Standard)
0 Images1-Hydroxypyrene (Standard) is the analytical standard of 1-Hydroxypyrene (HY-W014075). This product is intended for research and analytical applications. 1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes. 1-Hydroxypyrene is the orally active agonist for aryl hydrocarbon receptor (AhR) and can lead to renal fibrosis.
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L-Kynurenine-d4-1
0 ImagesL-Kynurenine-d4-1 is deuterium labeled L-Kynurenine. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.
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Tapinarof (Standard)
0 ImagesSynonyms: WBI-1001 (Standard); Benvitimod (Standard); GSK2894512 (Standard)Tapinarof (Standard) is the analytical standard of Tapinarof. This product is intended for research and analytical applications. Tapinarof (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM. Tapinarof resolves skin inflammation in mice.
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Potassium 1H-indol-3-yl sulfate (Standard)
0 ImagesPotassium 1H-indol-3-yl sulfate (Standard) is the analytical standard of Potassium 1H-indol-3-yl sulfate (HY-W011910). This product is intended for research and analytical applications. Potassium 1H-indol-3-yl sulfate is a metabolite of tryptophan, produced by intestinal microorganisms and combined with sulfate in the liver before entering the circulatory system. Potassium 1H-indol-3-yl sulfate is a potent endogenous agonist of the aryl hydrocarbon receptor (AhR) and a urinary toxin. Potassium 1H-indol-3-yl sulfate can be used for research on kidney diseases.
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5F-203 (Standard)
0 ImagesCat. No.: HY-124421RCAS No.: 260443-89-8Synonyms: NSC-703786 (Standard)5F-203 (Standard) (NSC-703786 (Standard)) is the analytical standard of 5F-203 (HY-124421). This product is intended for research and analytical applications. 5F-203 (NSC-703786) is an aryl hydrocarbon receptor (AhR) agonist and the active moiety of the water-soluble benzothiazole prodrug Phortress (HY-103223). 5F-203 binds to cytosolic AhR and induces CYP1A1 and CYP1B1 expression. 5F-203 activates AhR signaling to induce DNA damage, cell cycle arrest, apoptosis, caspase-3/-7 activation, lysosomal membrane permeabilization, and Cathepsin B release. 5F-203 induces CYGB and pro-apoptotic protein expression and NAG-1 mRNA/protein induction through RNA stabilization. 5F-203 is used in research related to cancers such as triple-negative breast cancer and colorectal cancer.
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6-Hydroxymusizin 8-O-glucoside
0 ImagesCat. No.: HY-N20739CAS No.: 23566-96-36-Hydroxymusizin 8-O-glucoside is a natural glycoside compound found in the seeds of Cassia obtusifolia, which weakly activates the Aryl Hydrocarbon Receptor (AhR). 6-Hydroxymusizin 8-O-glucoside can be used in studies on natural AhR ligands and dietary AhR signal regulation.
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Tapinarof-d5
0 ImagesCat. No.: HY-109044SCAS No.: 2748997-80-8Synonyms: WBI-1001-d5; Benvitimod-d5; GSK2894512-d5Tapinarof-d5 (WBI-1001-d5) is deuterium labeled Tapinarof. Tapinarof (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM. Tapinarof resolves skin inflammation in mice.
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L-Kynurenine-13C10 sulfate
0 ImagesCat. No.: HY-104026BSL-Kynurenine-13C10 (sulfate) is the 13C labeled L-Kynurenine sulfate. L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype.
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ITE (Standard)
0 ImagesITE (Standard) is the analytical standard of ITE. This product is intended for research and analytical applications. ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), binding directly to AHR, with a Ki of 3 nM. ITE also has immunosuppressive activity.
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MeBIO (Standard)
0 ImagesCat. No.: HY-103221RCAS No.: 667463-95-8
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Pifithrin-α hydrobromide (Standard)
0 ImagesCat. No.: HY-15484RCAS No.: 63208-82-2Synonyms: Pifithrin hydrobromide (Standard); PFTα hydrobromide (Standard)Pifithrin-α (hydrobromide) (Standard) is the analytical standard of Pifithrin-α (hydrobromide). This product is intended for research and analytical applications. Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.
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Picoberin
0 ImagesCat. No.: HY-148637CAS No.: 3034663-23-2Picoberin is a low picomolar inhibitor of Hedgehog-induced osteoblast differentiation. Picoberin is a potent aryl hydrocarbon receptor (AhR) agonist. Picoberin inhibits Wnt3A-induced osteoblast differentiation of C3H10T1/2 cells. Picoberin can upregulate genes encoding phase I and II metabolic enzymes.
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Lupinalbin A
0 ImagesCat. No.: HY-N4069CAS No.: 98094-87-2Synonyms: Boeravinone LLupinalbin A (Boeravinone L) is a dipeptidyl peptidase 4 (DPP4) and α-glucosidase inhibitor with IC50 values of 45.2 and 53.4 µM, respectively. Lupinalbin A exhibits antidiabetic activity.
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Sudan IV-d6
0 ImagesCat. No.: HY-D0932SCAS No.: 1014689-18-9Synonyms: Solvent Red 24-d6; C.I. 26105-d6Sudan IV-d6 (Solvent Red 24-d6) is the deuterium labeled Sudan IV(HY-D0932). Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections.
